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While most patients with COVID-19 recover completely within a few weeks, some people have symptoms that last for weeks or even months after the acute illness has passed. The symptoms are diverse, ranging from moderate to severe, and they can impact both young and elderly people, despite the severity of their COVID-19 symptoms in the acute stage. The RECLAIM Trial is a Canada-wide adaptive platform trial attempting to identify interventions that address the pathogenic mechanisms for Long COVID. 

Some Long COVID Symptoms Can Include:

  • Post-viral Cough/ Runny Nose/ Post-nasal Drip/ Sinus Congestion

  • Shortness of Breath on Exertion/ Chest Discomfort

  • Postural Orthostatic Tachycardia Syndrome (POTS)

  • Headaches

  • Sleep Disturbances

  • Anxiety/ Depression/ Post-traumatic Stress Disorder

 A group of individuals wearing masks in a public setting. The masks cover their noses and mouths, providing a protective barrier.

Adaptive Plaform Trial Design

RECLAIM is a pragmatic, prospective, adaptive randomized controlled platform trial designed to investigate different interventions for patients with long COVID.

In a traditional clinical trial, participants are randomly assigned to one of several interventions from a short list of options. An adaptive design is one that allows for prospectively planned changes to the trial and/or statistical procedures after the trial has begun which allows for flexibility in finding interventions that are effective and efficient. 


This means participants who are eligible to participate in RECLAIM will be randomly assigned to one of several interventions. Once a treatment is found to be effective for participants, this can help guide the intervention for new participants joining the study.

Participants will be seen at screening, baseline/randomization, 1 month, 2 months, 3 months, and 6 months after the baseline. They will also be able to enter weekly self-reported data into a database for up to 6 months from baseline. They will be required to be seen in-person in the clinic for at least two visits, at baseline and 2 months

Participants will be randomly assigned at the baseline/randomization visit to one of several arms and will continue on their assigned intervention for the duration of the treatment. (duration of the intervention may vary)

Our primary outcome is a health-related quality of life at two months.

Eligible Patient

Patients can be on stable standard of care interventions for symptom relief.


Patients will be randomized to one of several arms.


Testing multiple interventions that targets the cause of Long COVID.

Post-Intervention Follow up

Test interventions to get to the root cause of Long COVID, in addition to using standard of care interventions for relief of symptoms. 

Trial Sites


  • University Health Network *

  • Ottawa Hospital Research Institute *

  • Sinai Health System *


  • Université de Sherbrooke *

  • Centre hospitalier de l'Université de Montréal (CHUM) *


  • University of British Columbia

  • Providence Health


  • University of Calgary

* All active sites

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